He appeared in both English and Spanish-language commercials for "1-800-OK-Cable".
Giraldo said on Late Night with Conan O'Brien on July 7, 2005, that he had quit drinking alcohol.
Midlife Vices, his only one-hour special for Comedy Central, was released in 2009.
In June 2010, Giraldo performed at the Bonnaroo Music and Arts Festival in Tennessee.
Giraldo served as a judge during season seven of the NBC reality competition show Last Comic Standing.
This 98-minute film is thought by many of his fans to be one of his best performances—showing him on stage at work and also behind the scenes, with a glimpse of life on the road as a comedian.I can do that.' And I went from there." In 2004, he was featured in the spoken-word Lazyboy song "Underwear Goes Inside the Pants." Giraldo performed more than a dozen times on Late Night with Conan O'Brien, Late Show with David Letterman, and Jimmy Kimmel Live! He also appeared as a member of the panel in the NBC show The Marriage Ref.Giraldo acted in two Adam Dubin features, 2002's comedic short American Dummy, in which he played a psychiatrist, and 2008's animated film, What Blows Up Must Come Down! He appeared on The Late Late Show with Craig Kilborn, Politically Incorrect, The View, Fox News Channel's The Full Nelson and Beyond the News, Louie Anderson's Comedy Showcase, Comedy Central's Comic Cabana, Showtime's Latino Comedy Festival and Funny is Funny, as well as on the BBC's Live at Jongleurs. Giraldo (December 10, 1965 – September 29, 2010) was an American stand-up comedian, television personality, and lawyer.He is remembered for his appearances on Comedy Central's televised roast specials, and for his work on that network's television shows Tough Crowd with Colin Quinn, Lewis Black's Root of All Evil, and the programming block Stand-Up Nation, the last of which he hosted.